Title: targeting lymphoma-associated macrophage expansion via csf-1r/jak inhibition is a therapeutic vulnerability in peripheral t cell lymphomas authors: xin gao , nermin kady , chenguang wang , suhaib abdelrahman , peter gann , maria sverdlov , ashley wolfe , noah brown , john reneau , aaron m. robida , carlos murga-zamalloa , ryan a. wilcox affiliations: department of internal medicine, division of hematology and oncology, university of michigan; ann arbor, mi, usa department of pathology, university of illinois chicago; chicago, mi, usa. department of pathology, university of michigan; ann arbor, mi, usa. department of medicine, division of hematology, the ohio state university comprehensive cancer center; columbus, oh, usa. life sciences institute, university of michigan; ann arbor, mi, usa. running title: pacritinib inhibits lam expansion and ptcl progression abbreviations : aitl: angioimmunoblastic t-cell lymphoma cfcm: cell free conditioned media ctcl: cutaneous t-cell lymphoma fdc: follicular dendritic cell gem: genetically engineered mouse lam: lymphoma-associated macrophage mafia: macrophage fas-induced apoptosis mono/mac: monocyte/macrophage nk: natural killer ptcl: peripheral t-cell lymphoma tme: tumor microenvironment *correspondence to : ryan a. wilcox, md, phd, university of michigan rogel cancer center, 4310 cancer center, 1500 east medical center drive, ann arbor, mi 48109; phone: 734-615-9799; fax: 734-647-9654; e-mail: rywilcox@med.umich.edu. disclosure of conflicts of interest: the authors declare no potential conflicts of interest