Tlr4 modulates senescence and paracrine action in placental mesenchymal stem cells via inhibiting hedgehog signaling pathway in preeclampsia

HIGHLIGHTS

  • who: Yanqi Zhong and colleagues from the Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China have published the article: TLR4 Modulates Senescence and Paracrine Action in Placental Mesenchymal Stem Cells via Inhibiting Hedgehog Signaling Pathway in Preeclampsia, in the Journal: Oxidative Medicine and Cellular Longevity of 14/06/2022
  • what: This study was aimed at demonstrating that TLR4/HH pathway modulated senescence of placentas and PMSCs in vitro and in vivo. The authors found that preeclamptic PMSCs showed accelerated senescence with dysfunction, which is consistent . . .

     

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