Tlr7 agonism accelerates disease in a mouse model of primary sjögren’s syndrome and drives expansion of t-bet+ b cells

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• who: Achamaporn Punnanitinont from the University of Surrey, United Kingdom have published the Article: TLR7 agonism accelerates disease in a mouse model of primary Sju00f6grenu2019s syndrome and drives expansion of T-bet+ B cells, in the Journal: (JOURNAL)
• what: The authors focused the analyses on ANA-specific IgM and IgG . Female-derived ABCs from this model showed an enhanced IFNgene signature as compared to ABCs derived from male counterparts. This work has important therapeutic relevance, as targeting of TLR7-dependent signaling networks may be efficacious in reducing B cell activation and tissue-specific inflammation that . . .
  

   

  

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