Tnea therapy promotes the autophagic degradation of nlrp3 inflammasome in a transgenic mouse model of alzheimer’s disease via tfeb/tfe3 activation

HIGHLIGHTS

  • who: Wenjia Lin from the Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China have published the article: TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimeru2019s disease via TFEB/TFE3 activation, in the Journal: (JOURNAL)
  • how: The results showed that neither GB13-EA nor GV24-EA reduced the level of pro-/cleaved IL1B (Fig 2G and H) indicating the synergetic effect of GB13 and GV24 combination in inhibiting NLRP3 inflammasome. The results showed that large ASC specks were colocalized with SQSTM1 punctae in the CA3 region of HI . . .

     

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