Tnf- and il-1 modulate blood-brain barrier permeability and decrease amyloid- peptide efflux in a human blood-brain barrier model

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  • who: Romain Versele et al. from the Laboratoire de la Barriu00e8re Hu00e9mato-Encu00e9phalique (LBHE), UR, Universitu00e9 d`Artois, Lens, France have published the paper: TNF- and IL-1 Modulate Blood-Brain Barrier Permeability and Decrease Amyloid- Peptide Efflux in a Human Blood-Brain Barrier Model, in the Journal: (JOURNAL) of 31/01/2013
  • what: This study was designed to investigate whether TNF-u03b1 and IL-1u03b2 (to mimic CNS inflammation) can modulate the BBB properties and contribute to the development of AD pathology by altering Au03b2 peptide transport. Similarly, IL-1u03b2 treatment significantly increased the . . .

     

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