Tob1 attenuates irf3-directed antiviral responses by recruiting hdac8 to specifically suppress ifn-β expression

HIGHLIGHTS

• who: Zhongxia Yu from the School Shandong University Jinan, Shandong Province, China have published the Article: TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-u03b2 expression, in the Journal: (JOURNAL) of 24/Nov/2021
• what: The authors determined that viral infection markedly induced the interaction of with IRF3 which is bound to the promoter region of Ifnb1 in macrophages. thereby inhibited Ifnb1 transcription by disrupting IRF3 binding and recruiting histone deacetylase 8 (HDAC8) to the Ifnb1 promoter region.
• how: The authors examined the association between and IRF3 to . . .
  

   

  

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