Toosendanin activates caspase-1 and induces maturation of il-1β to inhibit type 2 porcine reproductive and respiratory syndrome virus replication via an ifi16-dependent pathway

HIGHLIGHTS

• who: Mingxin Zhang from the China Agricultural University, Guangzhou, China have published the paper: Toosendanin activates caspase-1 and induces maturation of IL-1u03b2 to inhibit type 2 porcine reproductive and respiratory syndrome virus replication via an IFI16-dependent pathway, in the Journal: (JOURNAL)
• what: The authors report that (TSN) a tetracyclic triterpene found in the bark or fruits of Melia toosendan Sieb. et Zucc. strongly suppressed type 2 PRRSV replication in vitro in Marc-145 cells and ex vivo in primary alveolar macrophages (PAMs) at sub-micromolar concentrations. The authors show that TSN potently . . .
  

   

  

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