Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses

HIGHLIGHTS

• who: John R. Ostergaard from the IRCCS Institute of Neurological Sciences of Bologna (ISNB), Italy University of Verona, Italy have published the paper: Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses, in the Journal: (JOURNAL)
• what: The authors show that depending on the genotype-phenotype relationship in CLN1 disease, the varied occurrence of age of onset and progression of CLN1 disease phenotypes, whether they be infantile or juvenile, still fits with the proposed hypothesis. This study shows that there is a great difference in the progression of clinical symptomatology and . . .
  

   

  

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