HIGHLIGHTS
- who: Anika Wiegard from the Department s of Health, Rockville, MD, USA University of have published the research: Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1, in the Journal: (JOURNAL) of December/16,/2021
- what: The authors show that RNAPII and TOP1 dissociate from genes as mitosis initiates and re-associate in the middle of mitosis (mid mitosis) for the first pioneering round of transcription. The authors propose that TOP1 activity during mitotic transcription is more important than during interphase to remove supercoiling that would otherwise oppose RNAPII elongation and . . .
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