HIGHLIGHTS
- who: Alexandre Nore from the (UNIVERSITY) have published the Article: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks, in the Journal: (JOURNAL) of 27/09/2022
- what: The authors show that REC114 is a direct partner of TOPOVIBL, and identify their conserved interacting domains by structural analysis. The authors propose that the TOPOVIBL-REC114 interaction is specifically required at sub-telomeric regions for full DSB activity and therefore, is essential for X/Y chromosome synapsis and segregation. The authors propose that TOPOVIBL can bind simultaneously to SPO11 through its transducer domain and to REC114 . . .
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