Total synthesis of floyocidin b: 4,5-regioselective functionalization of 2-chloropyridines

HIGHLIGHTS

  • who: Yolanda Kleiner and collaborators from the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen, Germany have published the Article: Total Synthesis of Floyocidin B: 4,5-Regioselective Functionalization of 2-Chloropyridines, in the Journal: Chemistry 2022, 4, FOR PEER REVIEW of /2022/
  • what: __SECTION__ 4. Conclusions.

SUMMARY

    Retrosynthetically, which is advantageous for structure-activity (SAR) investigations. opment of the total syntheses of 2 and 4 wasrelationship performed simultaneously, and allRetrosyngathered intermediate 5 was simplified to 2-chloro-4,5-substituted pyridines 6, which should be . . .

     

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