Toward consensus on correct interpretation of protein binding in plasma and other biological matrices for covid‐19 therapeutic development

HIGHLIGHTS

• who: Toward Consensus on Correct et al. from the Department University of have published the paper: Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID‐19 Therapeutic Development, in the Journal: (JOURNAL) of September/23,/2020

SUMMARY

There is a high risk of misinterpreting the comparison of in_vitro potency to in_vivo efficacious concentrations because such comparisons need to be made based on the free concentrations both in_vivo and in_vitro. Equally important, the case for utility of lopinavir even in HIV is diminished if plasma free drug . . .

 



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