Toward quantitative models in safety assessment: a case study to show impact of dose-response inference on herg inhibition models

HIGHLIGHTS

• who: Fjodor Melnikov and colleagues from the Department of Safety Assessment, Genentech, Inc, South San Francisco, CA, USA have published the Article: Toward Quantitative Models in Safety Assessment: A Case Study to Show Impact of Dose-Response Inference on hERG Inhibition Models, in the Journal: (JOURNAL)
• what: The majority of the recent models focused on classifying hERG inhibition at 10 u00b5M or at multiple thresholds . The authors demonstrate the impact of historical data processing on model performance. The authors demonstrate the benefits of the quantitative approach and discuss its practical uses in drug development. The . . .
  

   

  

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