Toxic and phenotypic effects of aav_cre used to transduce mesencephalic dopaminergic neurons

HIGHLIGHTS

• who: Larissa Erben and colleagues from the Human Development, National Institutes of Health, Bethesda, MD, USA have published the article: Toxic and Phenotypic Effects of AAV_Cre Used to Transduce Mesencephalic Dopaminergic Neurons, in the Journal: (JOURNAL) of 30/06/2022
• what: The authors report that AAV_Cre microinjection in the ventral tegmental area (VTA) of ErbB4 Cyt-1-floxed (ErbB4 Cyt-1fl/fl ) mice at titers commonly used in the literature (~1012 -1013 GC/mL) can have neurotoxic effects on and elicit behavioral abnormalities. Here the authors demonstrate that the effects of AAV_Cre are independent of . . .
  

   

  

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