HIGHLIGHTS
SUMMARY
Using cell cultures and in_vivo experiments with mice, it has been shown that ASYN can be transmitted between neurons and interact with the host´s ASYN and mitochondria. The authors tested the seeding hypothesis by investigating the effect of orally administered rotenone on ASYN knock-out (ASYN KO) mice and dissect the role of ASYN-ASYN and ASYN-mitochondria interactions by comparing the effect of extracellular ASYN monomers and oligomers on dopaminergic neurons in primary mesencephalic neuronal cultures from wild-type, ASYN KO, TH-GFP and TH-GFP/ASYN KO mice. To understand whether . . .
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