Toxicology evaluation of overdose hydroxychloroquine on zebrafish (danio rerio) embryos

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SUMMARY

    Zebrafish embryo mortality was recorded at 8 h postfertilization (hpf), 1 day postfertilization (dpf), 2 dpf, 3 dpf, and 4 dpf under the influence of 0 μM, 12.5 μM, 25 μM, 50 μM, 100 μM, and 200 μM HCQ that was administered at 0 hpf. The cumulative mortality of the control and experimental groups at concentrations of HCQ not exceeding 50 μM remained low (p > 0.05) as follows: 0 μM (0.0%), 12.5 μM (5.9%), 25 μM (3.6%), and 50 μM (0.0%). Prior to completion of 1 dpf . . .

     

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