Tpx2 enhances the transcription factor activation of pxr and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

HIGHLIGHTS

• who: Hongbo Wang from the Agents: vectors and antitumor drugs Antitumor drugsAntitumor drugs included tyrosine kinase inhibitor (TKIs) sorafenib, lenvatinib, regorafenib, and cabozantinib were synthesized by Professor and Dr. Cao Shuang at Wuhan Engineering University (Wuhan, China) and the purity of these drugs` powders were >, % according to high-performance liquid chromatography (HPLC) as shown in Table, . Some cytotoxic chemotherapeutic agents, doxorubicin (Cat. No.:, ), paclitaxel (Cat. No.:, ), etoposide (Cat. No.:, ), and irinotecan (Cat. No.:, ), were purchased from Selleck Corporation, Houston, Texas, USA. For cellular experiments, the four TKIs, the three cytotoxic chemotherapeutic drugs, irinotecan, paclitaxel, and etoposide, and . . .
  

   

  

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