HIGHLIGHTS
SUMMARY
Yao et_al found that knocking out the TRAF6 gene could prevent the metastasis of esophageal squamous cell carcinoma cells in_vivo or in_vitro, studied the mechanism of metastasis, and enhanced that it was the result of ERK phosphorylation caused by the binding of the N-terminal of TRAF6 to Ras. Starczynowski et_al found that TRAF6 was relatively up-regulated at the gene level in both non-small cell lung cancer and small cell lung cancer, and overexpressed TRAF6 triggered Ras-dependent tumorigenesis. TRAF6 inhibits RIPK1-RIPK3-MLKL signaling axis in colorectal cancer cells Transient (Fig . . .
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