HIGHLIGHTS
- who: Tranilast and colleagues from the Kumamoto University: Kumamoto Daigaku have published the paper: Tranilast-Tyrosine Hybrid Molecule Exhibits Dual Activity: Suppression of Epithelial-Mesenchymal Transition and Induction of Cytotoxicity in Cancer Cells, in the Journal: (JOURNAL)
- what: The authors report the synthesis of a new hybrid molecule, tyrosine-conjugated TNL, and its unexpected dual activity against EMT and cell proliferation. The authors designed a hybrid molecule, TNL-T (Fig 1), by conjugating tyrosine to tranilast via a short linker.
- how: The authors hypothesized that introducing a tyrosine moiety would increase the intracellular . . .
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