Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ask1)-p38 pathway

HIGHLIGHTS

• who: Yusuke Hirata from the (UNIVERSITY) have published the Article: trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway, in the Journal: (JOURNAL) of March/29,/2017
• what: The authors show that EA did not increase ATP-induced reactive oxygen species generation but, rather, augmentedtheeffectsofcalcium/calmodulin-dependentkinaseII-dependent ASK1 activation. The authors have shown that TFAs such as EA, LEA, and TVA, but not their cis isomers, promote extracellular ATPinduced activation of the ASK1-p38 pathway and subsequent apoptosis.
• future: Taken together . . .
  

   

  

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