HIGHLIGHTS
SUMMARY
Timescaled haplotypic density analysis revealed that widespread acquisition of compensatory mutations was associated with transmission success of XDR strains. To avoid the inclusion of homoplastic sites, mainly due to independent acquisition of identical resistance conferring mutations in the phylogenetic reconstructions, the authors removed 610 variants located in genes and intergenic regions associated with drug resistance and bacterial fitness (Supplementary Nature Communications | 13:5105 Data 1). W148 drug resistance evolution All strains of the W148 clade were resistant against INH (katG S315T) and streptomycin (rpsL K43R), indicating that resistance to these drugs was already acquired . . .
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