Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

HIGHLIGHTS

• who: Ioana Olan from the University of, Babraham Research Campus, Cambridge, UK have published the article: Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 25/Oct/2019
• what: The authors characterize high-order chromatin structure alteration during oncogenic RAS-induced senescence (RIS), integrating HiC and high-resolution capture Hi-C (cHi-C) for selected regions, including senescence-relevant genes. The authors show that significantly altered EP contacts, associated with gene_expression changes, occur during RIS.
• future: Studies are required to understand how cohesin islands . . .
  

   

  

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