Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation

HIGHLIGHTS

• who: Kim Theilgaard-Mu00f6nch from the Faculty University of of Denmark, Lyngby, Denmark have published the research work: Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors applied a systematic approach to uncover how designated key transcriptional regulators (i.e., CEBPA and CEBPE) orchestrate sequential lineage-specification, cell cycle exit, and terminal differentiation at the promoter and enhancer level during hematopoietic differentiation. The authors demonstrate an almost exclusive sequential expression of CEBPA and CEBPE during early and late . . .
  

   

  

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