Transcription factor eb controls metabolic flexibility during exercise

HIGHLIGHTS

• who: Gelsomina Mansueto from the Institut e of Genetics and Medicine (TIGEM), Via Campi Flegrei, Pozzuoli, Naples, Italy University of have published the paper: Transcription Factor EB Controls Metabolic Flexibility during Exercise, in the Journal: (JOURNAL) of January/10,/2017
• what: The authors show that the calcineurin-TFEB axis plays a major role in the metabolic adaptations that occur during physical exercise. By using gain- and loss-of-function approaches, the authors show that TFEB regulates mitochondrial biogenesis and glucose uptake independently of PGC1a.
• how: The authors examined whether TFEB is the missing . . .
  

   

  

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