Transcription factors sp1 and hif2α mediate induction of the copper-transporting atpase (atp7a) gene in intestinal epithelial cells during hypoxia*

HIGHLIGHTS

• who: Liwei Xie from the Liwei Xie and James FCollins, From the Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida , Background: A hypoxia-inducible transcription factor (Hif2␣) mediates induction of intestinal iron and copper transporters during iron deficiency. Results: Specificity factor , (Sp1) is required for transcriptional induction of an intestinal copper transporter (Atp7a) by Hif2␣. Conclusions: Sp, and Hif2␣ may synergistically mediate the genetic response to iron deficiency. Significance: Understanding molecular mechanisms governing iron absorption may allow modulation of this process during disease states. Genes with G/C-rich promoters were up-regulated in . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.