HIGHLIGHTS
- who: Roberta Brambilla from the Universitu00e9 de Lausanne, Switzerland University of Milan, Italy have published the Article: Transcriptional abnormalities in induced pluripotent stem cell-derived oligodendrocytes of individuals with primary progressive multiple sclerosis, in the Journal: (JOURNAL)
- what: The work demonstrated that PPMS-derived OLs have an intrinsically abnormal transcriptional profile that could impact their ability to properly interact with the CNS environment, particularly neurons, thus leading to pathology.
- how: The authors provided one more example that hiPSCs are indeed a useful tool to learn about the phenotype function and potential pathological alterations . . .
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