Transcriptional activity mediated by β-catenin and tcf/lef family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines

HIGHLIGHTS

• who: Janna Fru00f6hlich from the InstitutUniversity have published the Article: Transcriptional activity mediated by u03b2-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines, in the Journal: Scientific Reports Scientific Reports

SUMMARY

TCF7 and TCF7L2 are the only TCF/LEF family members expressed in HT29 cells, while HCT116 cells express TCF7, TCF7L1, and TCF7L2. Compared to their wild_type (WT) counterparts, these cells showed much reduced TCF7, TCF7L1, and TCF7L2 transcript levels, and, importantly, had no detectable TCF/LEF protein expression (Fig 1b . . .

 



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