Transcriptional induction of the imd signaling pathway and associated antibacterial activity in the digestive tract of cat fleas (ctenocephalides felis)

HIGHLIGHTS

• What: The authors compared the transcriptional profiles of four representative IMD pathway genes (PGRP-LC, IMD, Relish, and PGRP-LB) from the digestive tract of C. felis following exposure to three different species of bacteria: Gram-negative Bartonella henselae (a flea-borne pathogen), Gram-negative Serratia marcescens (a model laboratory species), and Gram-positive Micrococcus luteus (a model laboratory species). This study provides evidence in C. felis that the upregulation of AMP transcripts coincides with the activation of the IMD pathway, different species of bacteria elicit distinct transcriptional profiles of the IMD pathway genes, and_(3) antibacterial . . .
  

   

  

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