HIGHLIGHTS
- who: James Davies from the Thomas Jefferson University, United States have published the article: Transcriptional programming of immunoregulatory responses in human Langerhans cells, in the Journal: (JOURNAL)
- what: In contrast, here the authors demonstrate that such immature LCs inefficiently induce Tregs, while a specific subset of immunocompetent LCs expressing CD86 are able to do so more effectively. The model proposes, that while epidermal signaling in the steady-state promotes LC immunoregulatory function, the disruption of cell-cell contacts coupled with inflammatory signaling induces LC immunogenic programming, via IRF1 and IRF1dependent transcriptional programmes .
- future . . .
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