HIGHLIGHTS
- who: Chozhavendan, Rathinam and Christoph, Klein from the Department, Hannover, Germany have published the article: Transcriptional Repressor Gfi1 Integrates Cytokine- Receptor Signals Controlling B-Cell Differentiation, in the Journal: (JOURNAL)
- what: The authors provide evidence that CLP1-dependent IL7-receptor mediated B cell differentiation is critically controlled by the transcriptional repressor Gfi1. The authors provide evidence that similar feedback mechanisms control early B cell development by integrating cytokine signals and negative circuit loops. The authors provide evidence that Gfi1 provides an important link between cytokine signalling and transcriptional regulation by modulating cytokine-receptor signalling.
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