HIGHLIGHTS
- who: Yuming Zhao and collaborators from the Beihang University, China have published the article: Transcriptome analysis reveals effects of leukemogenic SHP2 mutations in biosynthesis of amino acids signaling, in the Journal: (JOURNAL)
- how: These results indicated that the expression of SHP2 mutants leads to a remodeling of cellular metabolism. The data showed that the mRNA expression of ASNS PHGDH PSAT1 and SHMT2 involved in asparagine serine and glycine biosynthesis were significantly increased in cells expressing mutant SHP2.
SUMMARY
The authors found that DEGs caused by the expression of mutant SHP2 were . . .
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