Transferrin-enabled blood-brain barrier crossing manganese-based nanozyme for rebalancing the reactive oxygen species level in ischemic stroke

HIGHLIGHTS

  • who: Qianqian Zhao and colleagues from the Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People`s Hospital, Shanghai Jiao have published the Article: Transferrin-Enabled Blood-Brain Barrier Crossing Manganese-Based Nanozyme for Rebalancing the Reactive Oxygen Species Level in Ischemic Stroke, in the Journal: Pharmaceutics 2022, 1122 of /2022/
  • what: The authors designed a Tf-based EMT nanozyme to cross the BBB, and the authors demonstrated its excellent brain targeting in_vitro and in_vivo.

SUMMARY

    Accordingly, the authors established an in_vitro BBB model using brain endothelial (bEnd.3) cells . . .

     

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