Transforming growth factor-α attenuates n-methyl-d-aspartic acid toxicity in cortical cultures by preventing protein synthesis inhibition through an erk1/2-dependent mechanism*

HIGHLIGHTS

• who: Vale̕rie Petegnief from the (UNIVERSITY) have published the article: Transforming Growth Factor-α Attenuates N-Methyl-D-aspartic Acid Toxicity in Cortical Cultures by Preventing Protein Synthesis Inhibition through an Erk1/2-dependent Mechanism*, in the Journal: (JOURNAL) of January/21,/2003
• what: The authors show that TGF-␣ exerts a neuroprotective effect in cortical cell cultures subjected to an excitotoxic lesion. To find out the molecular mechanism underlying protein synthesis inhibition and recovery, the authors focused the study on two translation factors, namely eIF2␣ and eIF4E. eIF2␣ is a critical regulator of protein synthesis . . .
  

   

  

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