Transgenic expression of nrf2 induces a pro-reductive stress and adaptive cardiac remodeling in the mouse

HIGHLIGHTS

• who: Arun Jyothidasan et al. from the Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA have published the research work: Transgenic Expression of Nrf2 Induces a Pro-Reductive Stress and Adaptive Cardiac Remodeling in the Mouse, in the Journal: Genes 2022, 13, 1514. of /2022/
• what: NGS and GSEA enrichment revealed that enhanced Keap1-Nrf2 signaling in the myocardium promoted hundreds of ARE and downstream targets, even under unstressed conditions.
• how: One limitation of the study is that only male mice were used for sequencing however . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.