Transient fcho1/2seps15/rsap-2 nanoclusters prime the ap-2 clathrin adaptor for cargo binding

HIGHLIGHTS

• who: Li Ma from the Department University of of Medicine, Terrace Street, BST, Pittsburgh, PA, USA have published the paper: Transient Fcho1/2SEps15/RSAP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding, in the Journal: (JOURNAL)
• what: The authors show that arrayed Asp-ProPhe (DPF) motifs within early-arriving pioneers Eps15/R are differentially decoded by other pioneers Fcho1/2 and AP-2. structure of an Eps15/R m-homology domain complex reveals a spacing-dependent triad bound a mechanistically distinct way from mode of single binding to AP-2. To better . . .
  

   

  

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