Transient stabilization, rather than inhibition, of myc amplifies extrinsic apoptosis and therapeutic responses in refractory b-cell lymphoma

HIGHLIGHTS

• who: Colleen T. Harrington from the (UNIVERSITY) have published the research: Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma, in the Journal: (JOURNAL)
• what: The authors report that adding GSK-3u03b2 inhibitors to Dox significantly improves therapeutic apoptosis in B-cell lymphomas with inactive p53 and dissect the underlying molecular mechanisms.
• how: The model was developed in female NSG mice of 6-8 weeks at engraftment within the project Development of Pediatric PDX Models approved by the experimental ethic committee 26 (CEEA26-Gustave . . .
  

   

  

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