Translocation of activator of g-protein signaling 3 to the golgi apparatus in response to receptor activation and its effect on the trans-golgi network*

HIGHLIGHTS

• who: Sukru S. Oner from the Sukru SOner, Ali Vural1, and Stephen M. Lanier, From the Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina , Background: The AGS3䡠G␣i complex is regulated by a GPCR, but downstream signaling events are unknown. Results: Upon receptor activation, translocates to the Golgi apparatus, where it regulates events at the TGN. Conclusions: The AGS3䡠G␣i complex serves as a signal transducer for GPCRs. Significance: The regulated translocation of , offers unexpected mechanisms for modulating protein secretion and/or endosome recycling events at . . .
  

   

  

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