Transplantation of fecal microbiota from app/ps1 mice and alzheimer’s disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice

HIGHLIGHTS

• who: Yanxin Zhao and Xueyuan Liu from the Human Microbiology Institute, United States Winthrop University Hospital have published the Article: Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer's disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice, in the Journal: (JOURNAL)
• what: (C) Representative immunoblots on day 17 of the experiment showed p-perk and p-eif2a levels in the cerebral cortex. In the present study, WT recipient mice showed dysregulated gut microbiota and increased levels of cortical perk and eIF2α phosphorylation, exhibiting excessive ER stress.
 



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