HIGHLIGHTS
- who: Jayaprakash Mandal from the (UNIVERSITY) have published the Article: Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response, in the Journal: (JOURNAL)
- what: Aberrations in this activity have emerged as epigenomic mechanisms in cancer development that increase tumor clonal fitness and adaptability amidst various selection pressures. The aim of this review is to discuss how inactivating mutations in AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, affect DNA damage repair in tumor cells.
SUMMARY
Involved in various repair pathways. Those . . .
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