HIGHLIGHTS
SUMMARY
During menses, the epithelial_cells re-epithelialize the exposed surface and regenerate the new functionalis under the control of estrogen, while the glands remain in the basalis layer. The specific population of endometrial epithelial_cells with stemness are capable of regenerating endometrial epithelial structures. Although the existence of uterine epithelial_cells with stemness was hypothesized decades ago, the first functional report for putative endometrial epithelial or stromal stem_cells was in 2004. Utilization of endometrial epithelial_cells for cell therapy is hampered due to the extremely low yield and limited proliferation capacity of uterine endometrial cells. The authors established . . .
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