Treatment response to sglt2 inhibitors: from clinical characteristics to genetic variations

HIGHLIGHTS

  • who: Jasna Klen and Vita Dolu017ean from the Division of Surgery, Department of Abdominal Surgery, University Medical Centre Ljubljana have published the research: Treatment Response to SGLT2 Inhibitors: From Clinical Characteristics to Genetic Variations, in the Journal: (JOURNAL)
  • what: The study showed statistically significant lower mortality due to cardiovascular events (38% relative risk reduction), less hospitalization due to heart failure (35% relative risk reduction), and death from any cause (32% relative risk reduction). The study showed a significant impact of the UGT1A9*3 and UGT2B4*2 alleles on the steadystate pharmacokinetic parameters of canagliflozin and . . .

     

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