HIGHLIGHTS
- who: Yunhong Bai from the University of Iowa, Iowa City, IA, USA have published the Article: Treatment with IFB-088 Improves Neuropathy in CMT1A and CMT1B Mice, in the Journal: (JOURNAL)
- what: The authors show that the small-molecule IFB-088 is able to readjust protein homeostasis and to ameliorate disease features in two models of demyelinating CMT1, the MpzR98C/ + (CMT1B) and the C3-PMP22 (CMT1A) mice. For this study, the authors used the C3-PMP22 mice that carry 3-4 copies of the human PMP22 gene, and that is thought to represent the more . . .
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