Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination

HIGHLIGHTS

• who: Mihyun Hwang from the Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA have published the article: Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination, in the Journal: (JOURNAL)
• what: The authors focused on two timepoints, namely, the peak of disease (day 12 pi) coincident with demyelination and similar clinical scores between groups and a late timepoint (day 28 pi). Using neurotropic MHV-JHM infection as a model of acute encephalomyelitis resolving into a persistent infection associated with demyelination, the studies showed that Trem2 . . .
  

   

  

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