Treponema pallidum subsp. pallidum strains dal-1 and philadelphia 1 differ in generation times in vitro as well as during experimental rabbit infection

HIGHLIGHTS

• What: The authors determined that Treponema pallidum subsp. pallidum (TPA) DAL-1 (belonging to Nichols-like group of TPA strains) grew 1.53 (± 0.08) times faster compared to TPA Philadelphia 1 (SS14-like group) during in vitro cultivations. This study compared the growth characteristics of TPA DAL-1 (Nichols-like cluster) and Philadelphia 1 (SS14-like cluster) under in_vitro conditions and during experimental rabbit infection. The more exact qPCR ratios from both inoculum and testes sampled at the end of the experiment (14 days) were used to calculate treponemal multiplication. The experiments showed important growth differences . . .
  

   

  

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