Trim-away ubiquitinates and degrades lysine-less and n-terminally acetylated substrates

HIGHLIGHTS

• who: Leo Kiss from the (UNIVERSITY) have published the article: Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates, in the Journal: (JOURNAL) of 29/06/2022
• what: The authors show that while Trim-Away activation results in ubiquitination of both ligase and substrate, ligase ubiquitination is not required for substrate degradation. The authors show that the TRIM21 RING domain interacts Nature Communications | 14:2160 with ubiquitin-charged Ube2W and that mutating these interactions, or Ube2W dimerization, inhibits ligase autoubiquitination.
• how: The authors found that both constructs were capable of . . .
  

   

  

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