HIGHLIGHTS
- who: Mingli Fang from the Department of Surgery and Immunobiology and Transplant Science Center, TX, USA have published the research: TRIM18 is a critical regulator of viral myocarditis and organ inflammation, in the Journal: (JOURNAL)
- what: Mechanistically the authors show that TRIM18 recruits protein phosphatase 1A (PPM1A) to dephosphorylate TANK binding kinase 1 (TBK1) which inactivates TBK1 to block TBK1 from interacting with its upstream adaptors mitochondrial antiviral signaling (MAVS) and stimulator of interferon genes (STING) thereby dampening antiviral signaling during viral infections. The authors demonstrate an essential role of E3 ubiquitin ligase TRIM18 in . . .
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