HIGHLIGHTS
- who: Mengmeng Zhao from the (UNIVERSITY) have published the Article: TRIM4-mediated ubiquitination of NSP2 restricts porcine reproductive and respiratory syndrome virus proliferation, in the Journal: (JOURNAL)
- what: The result of the study showed that the titer of PRRSV was significantly inhibited by TRIM4 overexpression; TRIM4 small interfering RNA (siRNA) had the opposite effect against the PRRSV titer.
- how: The protease inhibitor MG132 (Sigma-Aldrich M7449) was used in the study. The results showed that TRIM4 significantly reduced the PRRSV titer (Fig 1A) and PRRSV genome copy number (Fig 1B). TRIM4 knockdown efficiency . . .
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