Trim40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity

HIGHLIGHTS

• who: Sujin Kang from the Mice C BL/ N wild-type male mice were obtained from the OrientBio and Trim40-/- male mice were generated on C BL/ N background using CRISPR/Cas, technique from Cyagen BiosciencesCRISPR guide RNA (gRNA) was used to target exon , region in the Trim40. Genotypes of mice were investigated using genomic DNA PCR. All mice were maintained in the specific pathogen-free facility of the Yonsei Laboratory Animal Research Center at Yonsei University according to Korean Food and Drug Administration. All mice were housed on a, hour light and, hour dark cycle with . . .
  

   

  

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