Trimethylamine n-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes

HIGHLIGHTS

• who: Chuanqiang Qu from the Hospital, Taiwan Loma Linda University, United States have published the Article: Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes, in the Journal: (JOURNAL)
• what: The authors explored whether TMAO treatment could induce pyroptosis of oligodendrocytes, contributing to white matter demyelination in hypertension. The authors focused on exploring whether TMAO was involved in the process of demyelination in SHR. The authors found that SHR, a typical animal model for hypertensive CSVD, spontaneously developed the loss of white matter volumes, and cerebrovascular inflammation with increasing age . . .
  

   

  

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