Trio-drug combination of sodium valproate, baclofen and thymoquinone exhibits synergistic anticonvulsant effects in rats and neuro-protective effects in hek-293 cells

HIGHLIGHTS

  • who: Faheem Hyder Pottoo and colleagues from the Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, POBox, Dammam, Saudi Arabia have published the article: Trio-Drug Combination of Sodium Valproate, Baclofen and Thymoquinone Exhibits Synergistic Anticonvulsant Effects in Rats and Neuro-Protective Effects in HEK-293 Cells, in the Journal: (JOURNAL)
  • what: The authors report the synergistic effect of combination; SVP (150 mg/kg) BFN (5 mg/kg) and THQ (40 mg/kg) against generalized seizures.
  • how: The authors investigated a progressive preclinical trial in rats whereby the test . . .

     

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